Cannabis Laws By State 2021

Marijuana laws are changing at a rapid pace across all 50 states, making things a bit confusing at times. In order to keep up with the ever-changing laws, DISA has provided this interactive map for information on legalization, medical use, recreational use, and anything in between.

Are you wondering what the marijuana laws are in your state?

This marijuana legalization map clearly defines the laws in each state and remains up-to-date with the latest changes on a monthly basis. It’s important to understand and respect the rules that vary across the U.S. regarding marijuana use, and whether you’re a visiting tourist, or a resident the following information will help you steer clear of any misunderstandings or trouble. Scroll over each state to learn more about their individual legalization laws.Last Updated: February 2021

Note: State status reflects current laws at time of update, not pending legislation or future dates upon which marijuana becomes available medicinally or recreationally. Check here

StateLegal StatusMedicinalDecriminalizedState Laws
AlabamaFully IllegalNoNoView State Laws
AlaskaFully LegalYesYesView State Laws
ArizonaFully LegalYesYesView State Laws
ArkansasMixedYesNoView State Laws
CaliforniaFully LegalYesYesView State Laws
ColoradoFully LegalYesYesView State Laws
ConnecticutMixedYesYesView State Laws
DelawareMixedYesYesView State Laws
District of ColumbiaFully LegalYesYesView State Laws
FloridaMixedYesNoView State Laws
GeorgiaMixedCBD Oil OnlyNoView State Laws
HawaiiMixedYesYesView State Laws
IdahoFully IllegalNoNoView State Laws
IllinoisFully LegalYesYesView State Laws
IndianaMixedCBD Oil OnlyNoView State Laws
IowaMixedCBD Oil OnlyNoView State Laws
KansasFully IllegalNoNoView State Laws
KentuckyMixedCBD Oil OnlyNoView State Laws
LouisianaMixedYesNoView State Laws
MaineFully LegalYesYesView State Laws
MarylandMixedYesYesView State Laws
MassachusettsFully LegalYesYesView State Laws
MichiganFully LegalYesYesView State Laws
MinnesotaMixedYesYesView State Laws
MississippiMixedYesYesView State Laws
MissouriMixedYesYesView State Laws
MontanaFully Legal*YesYes*View State Laws
NebraskaFully IllegalNoYesView State Laws
NevadaFully LegalYesYesView State Laws
New HampshireMixedYesYesView State Laws
New JerseyFully Legal*YesYes*View State Laws
New MexicoMixedYesYesView State Laws
New YorkMixedYesYesView State Laws
North CarolinaFully IllegalNoYesView State Laws
North DakotaMixedYesYesView State Laws
OhioMixedYesYesView State Laws
OklahomaMixedYesNoView State Laws
OregonFully LegalYesYesView State Laws
PennsylvaniaMixedYesNoView State Laws
Rhode IslandMixedYesYesView State Laws
South CarolinaFully IllegalNoNoView State Laws
South DakotaFully Legal*Yes*Yes*View State Laws
TennesseeFully IllegalNoNoView State Laws
TexasMixedCBD Oil OnlyNoView State Laws
UtahMixedYesNoView State Laws
VermontFully LegalYesYesView State Laws
VirginiaMixedCBD Oil OnlyYesView State Laws
WashingtonFully LegalYesYesView State Laws
West VirginiaMixedYesNoView State Laws
WisconsinMixedCBD Oil OnlyNoView State Laws
WyomingFully IllegalNoNoView State Laws

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Can CBD Protect You From COVID-19?

There is no evidence that CBD can stave off or treat COVID-19 — and for people who take certain medications, it may even cause harm.

https://www.everydayhealth.com/coronavirus/can-cbd-protect-you-from-covid-19/

original content from

Meryl Davids Landau

By Meryl Davids LandauMedically Reviewed by Justin Laube, MD

“That’s a risky roll of the dice,” says one longtime cannabis researcher about taking CBD as protection from COVID-19.

Perhaps it wasn’t surprising that ads touting cannabidiol (CBD) would spring up during the COVID-19 pandemic. After all, the cannabis derivative has been touted in recent years for its antiviral properties.

But this doesn’t mean it’s effective against the novel coronavirus. And for people who take certain medications, it may not be safe.

A Look at the Evidence (0r Lack Thereof)

CBD might one day prove to be helpful for people who have or who are recovering from a viral illness, but the current data don’t support its use with the coronavirus, says Jahan Marcu, PhD, a longtime cannabis researcher in New York City and editor in chief of the American Journal of Endocannibinoid Medicine.

“If you’re using CBD as a shield to protect yourself against the coronavirus, that’s a risky roll of the dice right now,” he says.

Those who study CBD have been alarmed by some of the claims being made by advertisers. The board of the International Association on Cannabinoid Medicines (IACM) put out a statement in March asking members not to amplify “false information that is circulating on the Internet.”ADVERTISINGSunil K. Aggarwal, MD, PhD, an integrative medicine physician who uses cannabis in his Seattle practice, notes that there is no evidence that CBD protects against coronavirus infection or effectively treats it, the same message the IACM is working to convey.

RELATED: Scientists Fast-Track Research for Coronavirus Treatment and Vaccine

What Exactly Is CBD?

Cannabis plants, which include both marijuana and hemp varieties, contain hundreds of different compounds. The most famous is tetrahydrocannabinol, commonly known as THC, which is the chemical that makes you high. Another is CBD, which does not create a high.

Hemp plants contain negligible amounts of THC, a key reason why companies have been able to sell a broad array of hemp products. CBD has been especially popular in recent years, with an explosion of offerings featuring the substance in everything from pills and tinctures to coffees and skin cream.

Many CBD products are sold online, with a growing number also available from dispensaries in states that have legalized medical or recreational cannabis.

RELATED: CBD: A User’s Guide

There’s Very Little Human Research

Despite CBD’s widespread availability, hardly any research has been conducted in human subjects. This is because laws governing the legality of cannabis make these investigations difficult.

The most widely researched use for CBD is for epilepsy, with the U.S. Food and Drug Administration (FDA) approving the first CBD-based drugEpidiolex, in 2018 to treat rare forms of the disease. The drug’s manufacturer, GW Research, tested it in hundreds of patients before getting approval.

For most other uses, much of the research has involved laboratory animals and test tubes. It is here that CBD has shown promising antiviral properties, as well as antibacterial and other effects, Dr. Marcu says.

CBD may also relieve anxiety and help you sleep, according to a tiny study of 15 people published in the Journal of Clinical Pharmacology back in 1981. Researchers found that patients with insomnia taking 160 milligrams of CBD before bed (but not lower doses) slept longer than those taking a placebo.

But as the IACM notes, no human studies have been published regarding CBD’s effects on the coronavirus.

RELATED: CBD Medication Reduces Seizures in Children on Multiple Anti-Epileptic Drugs, Researchers Find

CBD Is Not Side-Effect Free

Marketers touting CBD often point to a 2017 statement by the World Health Organization (WHO) that says in its pure state, “cannabidiol does not appear to have abuse potential or cause harm.”

But they rarely mention the rest of the WHO statement — that the organization “does not recommend cannabidiol for medical use.”

The chemical is not side-effect free, with people taking CBD reporting problems including diarrhea, fatigue, and vomiting, according to a 2019 review in Current Neuropharmacology.

Potential Drug Interactions

For people with chronic health conditions, another issue is the possibility that CBD might interact negatively with certain medications.

A report published on the U.S. National Library of Medicine site warns people on the seizure medications clobazam (Onfi and Sympazan) and valproic acid (Depakene) not to take CBD, since it can increase these drugs’ side effects or boost the risk of liver injury.

For many other medicines, CBD can impact how much of the drug circulates in the body. “CBD targets the same metabolizing enzymes in the liver as many common medications,” Marcu says. “If you’re on other medicines, you must proceed with caution.”Speak with your physician before taking CBD if you’re taking a drug such as a benzodiazepinesedative, the pain medicine celecoxib (Celebrex), the gastrointestinal (GI) drug omeprazole (Prilosec, Omesec), the heart pill nifedipine (Procardia), or many others.

RELATED: CBD Oil 101: Uses, Benefits, Side Effects, and More

If You Use CBD, Buy Only Quality Products

If you have consulted with your physician and decide you still want to use CBD, it’s crucial that you buy it from a reputable manufacturer, experts say. You’ll want a company that tests each batch of product and lists the batch number on the bottle itself, so you can link it to corresponding test results on the company’s website or via a phone call to customer service.

One giveaway a product isn’t up to snuff: It’s too cheap. Good CBD is costly, with a bottle of tincture typically selling for $60 or more. 

As for how much to take, your guess is as good as any. There haven’t been studies on the various dosages, so nobody really knows, Dr. Aggarwal says.

RELATED: CBD Is Everywhere, But How Do I Know What’s Safe?

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THE LATEST IN CORONAVIRUS

COVID-19 Lung Inflammation Reduced by CBD

October 30, 2020 Madeline Colli

The Dental College of Georgia (DCG) and the Medical College of Georgia, recently performed a study which produced results showing that cannabidiol (CBD), a non-psychoactive cannabinoid found in cannabis, reduces damage in the lungs spurred by cytokine storms caused by coronavirus (COVID-19).

A recent study from the Dental College of Georgia (DCG) (Augusta, Georgia) and the Medical College of Georgia (Augusta, Georgia) produced results showing that cannabidiol (CBD), a non-psychoactive cannabinoid found in cannabis, reduces damage in the lungs spurred by cytokine storms caused by coronavirus (COVID-19) (1). In an earlier study (2), the researchers illustrated that CBD can reduce inflammation and physical lung damage associated with adult respiratory distress syndrome (ARDS), along with improved oxygen levels. The new study revealed the mechanisms behind these earlier results, exhibiting that CBD normalizes levels of apelin, a peptide known to reduce inflammation. During a COVID-19 infection, levels of the apelin peptide are low. Results of this study have been published in the Journal of Cellular and Molecular Medicine (3).

In the authors ARDS model, blood levels of apelin (a crucial piece in regulation, bringing both blood pressure and inflammation down) had dropped close to zero and increased 20 times with CBD. In the instance that blood pressure gets too high, apelin levels rise up to help alleviate the pressure. It is assumed that apelin should also help normalize inflammation in the lungs and other related breathing difficulties linked to ARDS. “Ideally with ARDS it would increase in areas of the lungs where it’s needed to improve blood and oxygen flow to compensate and to protect,” said Dr. Babak Baban, DCG immunologist (1). In their ARDS model, apelin did neither of these. When CBD was administered, apelin increased.

Although with their current study, the authors reiterated that much more is still being studied and there is some animosity in regard to whether CBD or COVID-19 have a direct effect on apelin but they are continuing on their mission to find out. “It is an association; we don’t know yet about causative, but it is a very good indicator of the disease,” Baban said (1). What they have found so far is that the reductions in apelin could potentially be an early biomarker for ARDS and response to treatment efforts.

Based on their earlier study, the authors mentioned that the data supported the idea that the anti-inflammatory function of CBD may assist in reducing cytokine storm and mitigate the effects of exaggerated inflammation (2). Further adding that, “considering all potential regulatory effects of CBD as well as the vast distribution of endocannabinoid system in the body, it is plausible that CBD may be used as a therapeutic candidate in the treatment of various inflammatory conditions including COVID-19 and other virus-induced ARDS.”

Expanding from the researchers’ newest study, the next steps for their research would be to comprise a stronger understanding of the interactions between apelin, CBD, and COVID-19 as well as studying why apelin decreases during COVID-19 infections and how CBD increases those numbers. They will explore how eliminating apelin affects ARDS and if CBD is able to produce the same lung benefit without the peptide. It is assumed that COVID-19 suppresses some sort of reaction that then suppresses apelin and CBD interferes with this process. Nonetheless, the authors doubt the apelin-CBD interaction is the only means by which the compound works in this or other scenarios.

Moving forward with their studies, the authors have refined a safe, relatively inexpensive model of ARDS by giving a synthetic analogue of double-stranded ribonucleic acid (RNA) called POLY (I:C). COVID-19 has double-stranded RNA, while human deoxyribonucleic acid (DNA) is single-stranded. The researchers’ model propagated a response similar to the virus, along with the extreme lung damage and cytokine storm, reflecting an overactive immune response in the lungs.

Gathering data for these studies, a control group received intranasal saline consecutively for three days while the COVID-19 model received POLY (I:C) intranasally for three days. Then there was a third group, known as the “treatment group,” who received POLY (I:C) and CBD over the same timeframe. The results produced significantly reduced apelin levels in the mice who had developed COVID-19-like symptoms compared to controls, and treatment with CBD normalized the immune response, apelin levels, oxygen levels, swelling, and scarring in the lungs.

CBD has shown itself to be a natural apelin agonist. Apelin levels are consistently measurable in the lungs, which is one of the reasons it proves to be a good biomarker. Aside from CBD, other cannabinoids, such as tetrahydrocannabinol (THC), are proving themselves beneficial in the fight against COVID-19 by decreasing the risk of cytokine storms, ARDS, and mortality (4,5). With future research, cannabis may prove itself useful in strengthening the side of those battling the virus and others fighting to rid the world of COVID-19.

References:

  1. https://www.healtheuropa.eu/cbd-reduces-covid-19-lung-damage-with-protective-peptides/103374/#:~:text=In%20a%20new%20study%2C%20scientists,levels%20of%20a%20natural%20peptide
  2. https://www.cannabissciencetech.com/view/evidence-grows-for-cbd-as-potential-covid-19-treatment
  3. https://onlinelibrary.wiley.com/journal/15824934
  4. https://www.cannabissciencetech.com/view/a-storm-of-research-activity-into-cannabis-and-coronavirus-a-closer-look-at-expanding-research-of-cannabinoids-and-terpenes-in-covid-19
  5. https://www.cannabissciencetech.com/view/treating-immunocompromised-patients-during-the-covid-19-pandemic-a-conversation-with-dr-bonni-goldstein

CBD For Coronavirus? New Study Adds Evidence For Cannabis As Covid-19 Treatment

Article from FORBES

CBD from cannabis could become the next COVID-19 treatment - according to new study.
CBD from cannabis could become the next COVID-19 treatment – according to new study. GETTY

As we continue to see outbreaks of the novel coronavirus surging, many are waiting and hoping for treatments to be developed that might treat, cure or prevent the potentially deadly disease. In a surprising turn of events, cannabis is on the list of potential treatments. 

While researchers are exploring many different possibilities in combating COVID-19, some researchers are looking into whether cannabis or cannabis derived CBD might offer benefits for those suffering from severe forms of this infection. Interestingly, there have been several different ways researchers have suggested CBD might help, including its ability to reduce ACE2 expression and pro-inflammatory cytokine production to fight lung inflammation, and it’s potential as an antiviral. But few studies have tested these theories with actual experimentation.  

Now new evidence is adding support to the theory that cannabis derived CBD may help those suffering from the severe lung inflammation that occurs in more serious cases of COVID-19. The study from researchers at Augusta University in Georgia suggests  that CBD may positively impact ARDS or acute respiratory distress syndrome – a dangerous symptom in COVID-19 caused by an overactive inflammatory response. This is sometimes referred to as a ‘cytokine storm’. The authors of the study explain that “currently, other than supportive measures, there is no definitive cure for ARDS, illustrating the urgent need for creative and effective therapeutic modalities to treat this complex condition.”Cannabis and Coronavirus: The Highs and Lows of QuarantineWATCH4:24

But CBD may be able to help treat this dangerous symptom of COVID-19. The researchers suggest CBD may be able to help by reducing pro-inflammatory cytokine production, fighting off the storm. By reducing specific cytokines such as interleukin (IL)-6, IL-1b, and IL-17, we may be able to bring down the inflammation and thus end the respiratory distress and damage. And the results of these researchers’ experiments supported this theory. MORE FOR YOUCannabis May Reduce Deadly COVID-19 Lung Inflammation: Researchers Explain WhyNew Research Suggests Terpenes And CBD Work 2X’s Better For Covid-19 Inflammation Than CorticosteroidCannabis Shows Potential To Help And Harm In Coronavirus Cases: Experts Explain Why

The research itself was performed on mice, who were first given a treatment called Poly(I:C) to artificially induce ARDS, with symptoms similar to what we see in severe COVID-19 patients. This created a cytokine storm, reduced the blood oxygen saturation by 10%, and even produced structural damages to the lungs in mice subjects. Then after the mice were experiencing the cytokine storm and coinciding respiratory distress, they were given CBD. And the results showed just how powerful CBD can be when treating ARDS. “These symptoms were totally or partially reversed and returned to the level and condition of the normal after treatment with CBD” the authors report. 

Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19
Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19 GETTY

In particular, mice treated with CBD saw reduced expression of IL-6, an important marker for cytokine storms, and lowered the levels of other proinflammatory cytokines. While the Poly:(I:C) spiked inflammatory markers, “CBD treatment reversed all these inflammatory indices and partially re-established homeostasis” the authors explain. Mice treated with CBD also had increases in lymphocyte levels in their blood, which are important white blood cells for fighting off infections. 

Researchers on the study say that CBD could play an immunotherapeutic role in treating severe respiratory viral infections like COVID-19, based on the present findings. 

“The current data support the notion that the anti-inflammatory function of CBD may reduce cytokine storm and mitigate the effects of exaggerated inflammation” they explain. They add that “considering all potential regulatory effects of CBD as well as the vast distribution of endocannabinoid system in the body, it is plausible that CBD may be used as a therapeutic candidate in the treatment of various inflammatory conditions including COVID-19 and other virus-induced ARDS.”

More research could help us learn how cannabis and CBD can help fight coronavirus
More research could help us learn how cannabis and CBD can help fight the novel coronavirus GETTY

Of course, this is an early study, and more research needs to be done – particularly more research that tests this theory on actual human subjects with COVID-19 related ARDS. The authors point out that “obviously, more studies are required to expand and validate this therapeutic strategy.” 

While we may have to wait for more research before this is being used as an active treatment for COVID-19, this study gives us good reason to hope that CBD might eventually be harnessed to help fight ARDS. It also adds to the chorus of researchers and cannabis advocates suggesting that we look further into cannabis and its potential to fight this deadly disease.

BD For Coronavirus? New Study Adds Evidence For Cannabis As Covid-19 Treatment

Emily EarlenbaughContributorVicesI cover cannabis’ intersection with science, culture, and wellness.

CBD from cannabis could become the next COVID-19 treatment - according to new study.
CBD from cannabis could become the next COVID-19 treatment – according to new study. GETTY

As we continue to see outbreaks of the novel coronavirus surging, many are waiting and hoping for treatments to be developed that might treat, cure or prevent the potentially deadly disease. In a surprising turn of events, cannabis is on the list of potential treatments. 

While researchers are exploring many different possibilities in combating COVID-19, some researchers are looking into whether cannabis or cannabis derived CBD might offer benefits for those suffering from severe forms of this infection. Interestingly, there have been several different ways researchers have suggested CBD might help, including its ability to reduce ACE2 expression and pro-inflammatory cytokine production to fight lung inflammation, and it’s potential as an antiviral. But few studies have tested these theories with actual experimentation.  

Now new evidence is adding support to the theory that cannabis derived CBD may help those suffering from the severe lung inflammation that occurs in more serious cases of COVID-19. The study from researchers at Augusta University in Georgia suggests  that CBD may positively impact ARDS or acute respiratory distress syndrome – a dangerous symptom in COVID-19 caused by an overactive inflammatory response. This is sometimes referred to as a ‘cytokine storm’. The authors of the study explain that “currently, other than supportive measures, there is no definitive cure for ARDS, illustrating the urgent need for creative and effective therapeutic modalities to treat this complex condition.”Cannabis and Coronavirus: The Highs and Lows of QuarantineWATCH4:24

But CBD may be able to help treat this dangerous symptom of COVID-19. The researchers suggest CBD may be able to help by reducing pro-inflammatory cytokine production, fighting off the storm. By reducing specific cytokines such as interleukin (IL)-6, IL-1b, and IL-17, we may be able to bring down the inflammation and thus end the respiratory distress and damage. And the results of these researchers’ experiments supported this theory. MORE FOR YOUCannabis May Reduce Deadly COVID-19 Lung Inflammation: Researchers Explain WhyNew Research Suggests Terpenes And CBD Work 2X’s Better For Covid-19 Inflammation Than CorticosteroidCannabis Shows Potential To Help And Harm In Coronavirus Cases: Experts Explain Why

The research itself was performed on mice, who were first given a treatment called Poly(I:C) to artificially induce ARDS, with symptoms similar to what we see in severe COVID-19 patients. This created a cytokine storm, reduced the blood oxygen saturation by 10%, and even produced structural damages to the lungs in mice subjects. Then after the mice were experiencing the cytokine storm and coinciding respiratory distress, they were given CBD. And the results showed just how powerful CBD can be when treating ARDS. “These symptoms were totally or partially reversed and returned to the level and condition of the normal after treatment with CBD” the authors report. 

Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19
Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19 GETTY

In particular, mice treated with CBD saw reduced expression of IL-6, an important marker for cytokine storms, and lowered the levels of other proinflammatory cytokines. While the Poly:(I:C) spiked inflammatory markers, “CBD treatment reversed all these inflammatory indices and partially re-established homeostasis” the authors explain. Mice treated with CBD also had increases in lymphocyte levels in their blood, which are important white blood cells for fighting off infections. 

Researchers on the study say that CBD could play an immunotherapeutic role in treating severe respiratory viral infections like COVID-19, based on the present findings. 

“The current data support the notion that the anti-inflammatory function of CBD may reduce cytokine storm and mitigate the effects of exaggerated inflammation” they explain. They add that “considering all potential regulatory effects of CBD as well as the vast distribution of endocannabinoid system in the body, it is plausible that CBD may be used as a therapeutic candidate in the treatment of various inflammatory conditions including COVID-19 and other virus-induced ARDS.”

More research could help us learn how cannabis and CBD can help fight coronavirus
More research could help us learn how cannabis and CBD can help fight the novel coronavirus GETTY

Of course, this is an early study, and more research needs to be done – particularly more research that tests this theory on actual human subjects with COVID-19 related ARDS. The authors point out that “obviously, more studies are required to expand and validate this therapeutic strategy.” 

While we may have to wait for more research before this is being used as an active treatment for COVID-19, this study gives us good reason to hope that CBD might eventually be harnessed to help fight ARDS. It also adds to the chorus of researchers and cannabis advocates suggesting that we look further into cannabis and its potential to fight this deadly disease.

Emily EarlenbaughContributorVicesI cover cannabis’ intersection with science, culture, and wellness.

CBD from cannabis could become the next COVID-19 treatment - according to new study.
CBD from cannabis could become the next COVID-19 treatment – according to new study. GETTY

As we continue to see outbreaks of the novel coronavirus surging, many are waiting and hoping for treatments to be developed that might treat, cure or prevent the potentially deadly disease. In a surprising turn of events, cannabis is on the list of potential treatments. 

While researchers are exploring many different possibilities in combating COVID-19, some researchers are looking into whether cannabis or cannabis derived CBD might offer benefits for those suffering from severe forms of this infection. Interestingly, there have been several different ways researchers have suggested CBD might help, including its ability to reduce ACE2 expression and pro-inflammatory cytokine production to fight lung inflammation, and it’s potential as an antiviral. But few studies have tested these theories with actual experimentation.  

Now new evidence is adding support to the theory that cannabis derived CBD may help those suffering from the severe lung inflammation that occurs in more serious cases of COVID-19. The study from researchers at Augusta University in Georgia suggests  that CBD may positively impact ARDS or acute respiratory distress syndrome – a dangerous symptom in COVID-19 caused by an overactive inflammatory response. This is sometimes referred to as a ‘cytokine storm’. The authors of the study explain that “currently, other than supportive measures, there is no definitive cure for ARDS, illustrating the urgent need for creative and effective therapeutic modalities to treat this complex condition.”Cannabis and Coronavirus: The Highs and Lows of QuarantineWATCH4:24

But CBD may be able to help treat this dangerous symptom of COVID-19. The researchers suggest CBD may be able to help by reducing pro-inflammatory cytokine production, fighting off the storm. By reducing specific cytokines such as interleukin (IL)-6, IL-1b, and IL-17, we may be able to bring down the inflammation and thus end the respiratory distress and damage. And the results of these researchers’ experiments supported this theory. MORE FOR YOUCannabis May Reduce Deadly COVID-19 Lung Inflammation: Researchers Explain WhyNew Research Suggests Terpenes And CBD Work 2X’s Better For Covid-19 Inflammation Than CorticosteroidCannabis Shows Potential To Help And Harm In Coronavirus Cases: Experts Explain Why

The research itself was performed on mice, who were first given a treatment called Poly(I:C) to artificially induce ARDS, with symptoms similar to what we see in severe COVID-19 patients. This created a cytokine storm, reduced the blood oxygen saturation by 10%, and even produced structural damages to the lungs in mice subjects. Then after the mice were experiencing the cytokine storm and coinciding respiratory distress, they were given CBD. And the results showed just how powerful CBD can be when treating ARDS. “These symptoms were totally or partially reversed and returned to the level and condition of the normal after treatment with CBD” the authors report. 

Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19
Cannabis derived CBD may help fight off severe lung inflammation caused by COVID-19 GETTY

In particular, mice treated with CBD saw reduced expression of IL-6, an important marker for cytokine storms, and lowered the levels of other proinflammatory cytokines. While the Poly:(I:C) spiked inflammatory markers, “CBD treatment reversed all these inflammatory indices and partially re-established homeostasis” the authors explain. Mice treated with CBD also had increases in lymphocyte levels in their blood, which are important white blood cells for fighting off infections. 

Researchers on the study say that CBD could play an immunotherapeutic role in treating severe respiratory viral infections like COVID-19, based on the present findings. 

“The current data support the notion that the anti-inflammatory function of CBD may reduce cytokine storm and mitigate the effects of exaggerated inflammation” they explain. They add that “considering all potential regulatory effects of CBD as well as the vast distribution of endocannabinoid system in the body, it is plausible that CBD may be used as a therapeutic candidate in the treatment of various inflammatory conditions including COVID-19 and other virus-induced ARDS.”

More research could help us learn how cannabis and CBD can help fight coronavirus
More research could help us learn how cannabis and CBD can help fight the novel coronavirus GETTY

Of course, this is an early study, and more research needs to be done – particularly more research that tests this theory on actual human subjects with COVID-19 related ARDS. The authors point out that “obviously, more studies are required to expand and validate this therapeutic strategy.” 

While we may have to wait for more research before this is being used as an active treatment for COVID-19, this study gives us good reason to hope that CBD might eventually be harnessed to help fight ARDS. It also adds to the chorus of researchers and cannabis advocates suggesting that we look further into cannabis and its potential to fight this deadly disease.

CBD reduces COVID-19 lung damage with protective peptides

Article from Medical Cannabis Network

21st October 2020

https://www.healtheuropa.eu/cbd-reduces-covid-19-lung-damage-with-protective-peptides/103374/
CBD reduces COVID-19 lung damage with protective peptides
iStock-Stefan Tomic

In a new study, scientists have shown that one of the non-psychoactive cannabinoids in cannabis – CBD – reduces lung damage induced by cytokine storms caused by COVID-19 through enabling an increase in levels of a natural peptide.

The scientists, from the Dental College of Georgia (DCG) and the Medical College of Georgia, demonstrated earlier this year that CBD has the ability to improve oxygen levels and reduce inflammation and physical lung damage related to adult respiratory distress syndrome (ARDS). This new study has now shown the mechanisms behind these results, demonstrating that CBD normalises levels of a peptide named apelin, which is known to reduce inflammation. Levels of this peptide are low during a COVID-19 infection.

While the researchers say the peptide clearly has an important role to play, they do not attribute all CBD’s benefits to apelin. The results have been published in the Journal of Cellular and Molecular Medicine.

Reducing inflammation with CBD

Blood levels of apelin, which is an important regulator in bringing both blood pressure and inflammation down, dropped close to zero in the authors’ ARDS model and increased 20 times with CBD. When blood pressure gets high, for example, apelin levels should go up to help reduce the pressure. Apelin should do the same to help normalise inflammation in the lungs and related breathing difficulties associated with ARDS.

“Ideally with ARDS it would increase in areas of the lungs where it’s needed to improve blood and oxygen flow to compensate and to protect,” said Dr Babak Baban, DCG immunologist. But when the authors looked at their ARDS model, apelin did not do either, and instead decreased in both the lung tissue itself and the general circulation. However, this changed when they administered CBD.

The authors emphasise that they do not yet know whether the novel coronavirus or CBD have a direct effect on apelin, or if these are downstream consequences, however, they are already working to find out.

“It is an association; we don’t know yet about causative, but it is a very good indicator of the disease,” Baban said.

The authors note that the finding of dramatic reductions in apelin in the face of ARDS, makes levels of the protective peptide a potential early biomarker for ARDS and response to treatment efforts.

ACE2 receptor

The COVID-19 virus enters human cells via the also pervasive angiotensin-converting enzyme 2, otherwise known as the ACE2 receptor, with plenty of common ground between ACE2 and apelin, including the fact that many cell types and tissues have both, including the lungs.

Apelin and ACE2 normally work together to control blood pressure, and upregulation of both may be helpful in cardiovascular disease, including heart failure, by decreasing blood pressure while increasing the heart’s ability to pump.

The COVID-19 virus appears to upset this positive partnership, with the virus having the ability to bind to the receptor for ACE2. This has been shown to decrease ACE2 levels and increase levels of the powerful blood vessel constrictor angiotensin II, because less angiotensin II gets degraded and fewer vasodilators (chemicals that widen blood vessels) get produced, which worsens the patient’s prognosis.

“Instead of ACE2 helping blood vessels relax, it helps the virus get into the host where it makes more virus instead of helping the lungs relax and do their job,” says Yu.

CBD as a natural apelin agonist

The next steps in the research include better understanding the interaction between CBD, apelin, and the novel coronavirus, including why apelin goes down in the face of the virus and why CBD brings it up.

The researchers will be exploring how eliminating apelin affects ARDS and if CBD produces the same lung benefit without apelin. The authors note that it is likely the virus suppresses something that suppresses apelin and CBD interferes with this process, however, they also they doubt the apelin-CBD interaction is the only way the compound works in this and other scenarios.

To carry out the studies, the authors developed a safe, relatively inexpensive model of ARDS by giving a synthetic analogue of double-stranded RNA called POLY (I:C). The novel coronavirus also has double-stranded RNA, while human DNA is single-stranded. The model produced a response similar to the virus, including the extreme lung damage and the “cytokine storm” that reflects an over-the-top immune response in the lungs.

For these studies, a control group received intranasal saline for three consecutive days while the COVID-19 model received POLY (I:C) intranasally for three days. A third group, the treatment group, received POLY (I:C) and CBD over the same timeframe. The researchers found significantly reduced apelin levels in the mice that developed COVID-like symptoms compared to controls, and treatment with CBD normalised the immune response and apelin levels, along with oxygen levels, swelling, and scarring in the lungs.

“The apelinergic system is a very, very ubiquitous signalling system,” Yu says. The authors note that apelin has diverse jobs in different places and that its levels are consistently measurable in the lungs, one of the reasons it should be a good biomarker.

They add that CBD appears to be a natural apelin agonist.

Can CBD Make Sex Better? Here’s What the Experts Say

Top 10 Things You Need To Know Before Buying CBD

Can CBD really improve your sex life? Joni Sweet

Joni Sweet is a freelance writer who specializes in travel, health, and wellness. Her work has been published by National Geographic, Forbes, the Christian Science Monitor, Lonely Planet, Prevention, HealthyWay, Thrillist, and more. Keep up with her on Instagram and check out her portfolio.

Sex changed for Heather Huff-Bogart when she had her IUD removed. The once fun, pleasurable experience now left her “curled over in pain with cramps.” Eager to find a solution to the problem, she decided to try a personal lubricant infused with cannabidiol (CBD) about six months ago, and noticed immediate improvements.

“It helped reduce the pain and inflammation I have during intercourse. My husband noticed that I don’t complain as much about pain, and it’s been beneficial for both of us,” says Huff-Bogart.

While relatively new to the mainstream market, CBD is widely available in a variety of forms — from oils and tinctures to topical creams and beverages. Lately, CBD has also made its way into the bedroom. The substance can be found in a variety of products, all aimed at helping to improve users’ sex lives. These products include:

  • personal lubricants
  • massage lotions
  • oral sprays
  • edibles

But can CBD really improve your sex life?

Here’s what you need to know about the science of CBD and sex, as well as the intimate experiences people have had with cannabidiol.

How CBD can help improve sex

Folks look to CBD for sex for a number of reasons, including pain from chronic conditionsTrusted Source like endometriosis.

Other reasons include:

  • increasing pleasure
  • easing stress and anxiety, including performance anxiety
  • setting the right mood

When it comes to issues of lubrication during sex, Alex Capano, medical director for Ananda Hemp and faculty member at the Lambert Center for the Study of Medicinal Cannabis and Hemp at Thomas Jefferson University, explains that CBD may help.

“There are so many cannabinoid receptors in reproductive organs and sexual tissue. CBD increases blood flow to tissues, which increases sensitivity and promotes the body’s own natural lubrications,” says Capano.

For individuals like Allison Wallis, CBD helps foster relaxation for sex. Wallis has Ehlers-Danlos syndrome, a condition that causes joint subluxations and severe muscle spasms. She explains that she’s experienced the benefits of CBD firsthand when she tried a lubricant infused with cannabidiol.

“It relaxes my muscles and allows for much more enjoyable sex,” she says, adding that the lube induces a “feeling of warmth and relaxation.”

“I was surprised by how well it worked. It allowed me to focus on the intimacy of the act instead of my muscle spasms.”

It’s hard to say just how many people are using CBD in the bedroom, but a recent survey of 5,398 Americans from Remedy Review, a website that focuses on CBD and natural health remedies, found that 9.3 percent of respondents have taken CBD for sex. The majority of those respondents said their orgasms were more intense after taking CBD.

What’s more, CBD might just put some people in the mood for romance. Research shows that CBD may be effective at reducing stress and anxiety. That relaxation can, in turn, reduce the distractions and worries that can hinder a positive sexual experience.

“There’s an important component of calming the mind and really focusing on enjoying,” says Capano.

“Especially for women in heterosexual couples, who often experience the pressure of needing to orgasm.”

While CBD doesn’t have psychoactive affects, it may boost your mood by enhancing a neurotransmitter called anandamideTrusted Source.

“Anandamide is our bliss neurotransmitter, and it’s also associated with oxytocin [also known as the ‘cuddle hormone’],” says Capano. “CBD helps increase the natural neurotransmitters and endorphins that we make on our own that ultimately lead to a better sexual experience.”

Some experts are skeptical about CBD’s effects due to limited research

While early research has CBD enthusiasts excited about its potential for health and sexuality, some experts say more studies are needed before any firm conclusions can be drawn.

“There aren’t any studies on CBD for sexuality, and particularly for using it as a topical application,” says Dr. Jordan Tishler, a cannabis therapeutics specialist at InhaleMD and president of the Association of Cannabis Specialists.

“CBD is wholly ineffective for sexuality. The primary advantage is the lack of intoxication, leading to widespread acceptance [of the compound], even though it is simply a placebo.”

He believes that the focus should be on cannabis, which has “40-plus years of data” on its effect on sexuality.

CBD Sex

“For the treatment of sexual-related issues, I tend to recommend vaporized cannabis flower, because we know the THC actually helps with the four stages of sexuality: libido, arousal, orgasm, and satisfaction,” he says.

Sarah Ratliff, a 52-year-old woman who has been using marijuana for pain relief for many years, says she didn’t perceive any benefits from trying CBD oil. But when she tried smoking and vaping cannabis — which has both CBD and tetrahydrocannabinol (THC) — to improve her sex life, she noticed big improvements.

“It really helps me relax and let go of the day,” she says. “Sex was more intense after smoking, and I think it’s because it helps my inhibitions come down and allows my body to focus.”

However, doctors and health professionals who’ve seen improvements in patients’ sex lives say the anecdotal evidence has turned them into believers of CBD products, despite the lack of clinical trials.

Dr. Evan Goldstein says he’s seen firsthand the positive effect of CBD on his patients.

“These products work. They obviously need to be taken into context and used correctly, but they can enhance the experience and make things a little more pleasurable,” says Goldstein, the founder and CEO of Bespoke Surgical, an anal surgery practice that focuses on the sexual wellness, education, and comfort of the LGBTQ+ community.

“Most of my knowledge of the benefits of CBD is coming from my patients. But as we see this become more regulated, there will be more studies done.”

What to know about using CBD in the bedroom

If you’re interested in experimenting with CBD in your sex life, there are a few things to keep in mind. Here’s what to know about getting started:

Buy a quality product

Don’t just reach for any CBD product. Read reviews and check that a product has been verified by an independent lab before buying it.

You should also be aware that CBD can be derived from hemp or marijuana, and that marijuana-derived CBD products contain THC. The two cannabinoids may work best when used together, producing what experts call an “entourage effect.”

CBD and sex

Moreover, while both hemp and marijuana are cannabis plants, they differ in their THC content. Hemp must contain less than 0.3 percent to be legal at the federal level. Marijuana has a higher concentration of THC.

Find your ideal dose

When it comes to CBD dosing, everyone’s different, and there’s no conclusive evidence on exactly how much CBD someone should be taking for certain effects or health benefits.

“Start low and go slow,” says Capano. “Titrate up slowly every couple of days, and if you keep getting increased benefits, keep going. If you add more and don’t feel better or start to feel worse, go back to the previous dose.”

Use CBD before going into the bedroom

CBD doesn’t necessarily work the moment you decide to use it, whether you apply it as a lubricant or take it orally. Plan ahead and start taking it — or applying it — 30 to 60 minutes before you head into the bedroom to give it enough time to kick in.

And if you’re wondering why CBD isn’t working for you, check out some potential reasons here.

Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.

CBDDaily Products

CBD Daily Products

CBD Daily Products offers 100% Natural CBD Oil topical products since 1996. Effective, natural, sustainable, and ethical, PETA and Leaping Bunny certified.

Why Choose CBD Daily Products?

CBD Daily is a 100% natural CBD oil infused skin care line since 1996. Our products soothe and moisturize while reliving overall discomfort. We offer a range of natural Hemp CBD products in different forms and fragrances such as CBD Cream, CBD Serum, CBD Spray, CBD Lotion & CBD Massage Candle.

CBD Daily Products offers 100% Natural CBD Oil topical products since 1996. Effective, natural, sustainable, and ethical, PETA and Leaping Bunny certified.

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Earthly Body CBD Daily -CBD Daily is brought to you by Earthly Body, a respected, family-owned company that has been creating high-quality, hemp-based natural personal care products since 1996, It soothes and moisturizes while relieving overall discomfort. CBD Daily comes to you in a variety of forms to fit every lifestyle and needs.CBD Daily is a CBD-infused skin care line that addresses a wide variety of pain and soreness, and is especially useful for sore muscles and cramping.

Earthly Body uses natural ingredients – no mineral oil, dyes, sulfates, propylene glycol, phthalates or parabens. Earthly Body’s products are 100% Vegan, drug-free and cruelty-free. We are on PETA’s coveted and highly regarded “No Test List.”

High Climax Arousal Cream With CBD

Learn about the benefits of High Climax Arousal Cream With CBD

Female stimulating cream made with a high concentration of cannabis sativa seed oil and CBD. Enhances orgasms and increases pleasure.

High Climax is a powerful topical cream that amplifies sexual pleasure immediately upon contact. This highly concentrated clitoral stimulant contains the added benefits of Sativa seed oil and CBD oil to enhance orgasms and increase pleasure.

Increases the blood flow

The high climax CBD increases levels of energy by giving extra power to females. It consists of all-natural ingredients that keep the body safe & sound. It doesn’t leave any of the side effects on the body and keeps them healthy from within. 

It assists to increase blood flow by relaxing muscles and further enhances orgasms & increases the pleasure. You can make use of it as it offers better performance. It is available in the topical cream form which is easier for use on a regular basis. 

Easy to apply

You just need to apply a few drops of this high climax CBD topical cream to your clitoris. The sensation will automatically start within 5 minutes. In such a manner it can help you in getting ultimate power for performing great in bed. 

Improves sexual life

Apart from helping in building muscle mass, it enhances well the sexual life of a person. It keeps the body healthy and mood remains increased with a higher energy level. It assists to flush out the chemicals and toxins from the body and keeps them happy and healthy.

  • Sativa Oil
  • Packed with invigorating components like vitamins A, B, and C, calcium, potassium, magnesium, and zinc
  • Can assist in skin recovery & repair and improved elasticity
  • Known to be antioxidant, anti-inflammatory, antimicrobial and antifungal
  • May have the effect of contracting muscles, which improves performance.
  • CBD
  • Historically a natural aphrodisiac
  • Known increase libido, promote lubrication, and increase sensitivity
  • May increase the intensity and duration of female orgasms
  • Can decrease pain

Directions: Apply a few drops to the clitoris. Sensation will begin in approximately 3-5 minutes.

Warning: If irritation or discomfort occurs, discontinues use and consult a physician. Very slippery on surfaces, clean spills immediately. Keep out of reach of children and pets.

Ingredients: De-ionized Water, Aloe Barbadensis Aloe Vera Gel Juice, Stearic Acid, Cetyl Alcohol, Glycerin, Dimethicone, Helianthus Annuus Sunflower Oil, Zemea Corn Propanediol, Methyl Salicylate, Tocopheryl Acetate Vitamin E, Cannabis Sativa Hemp Seed Oil, Carrageenan, Lecithin, L-Arginine HCl, Niacin, Glycyrrhiza Glabra Licorice Root Extract, Panax Ginseng Root Extract, Tongkat Ali Extract, Citrullus Lanatus Watermelon Extract, Dioscorea Villosa Wild Yam Root Extract, Echinacea Purpurea Extract, Menthol, dl-Panthenol, Ascorbic Acid, Methyl Nicotinate, Parfum Fragrance, Sodium Hydroxide, Phenoxyethanol, Ethylhexylglycerin

CBD 420 Sale
Shop all of the CBD Pleasure products by clicking above

Learn About High Climax Arousal Cream with CBD Female stimulating cream made with a high concentration of cannabis sativa seed oil and CBD. Enhances orgasms and increases pleasure.

CBD 420 Code Word ” Cannibus”

CBD 420 SaleCBD HEALTH AND SEXUAL WELLNESS PRODUCTS

What is the Meaning of CBD 420 and How Did This Start?

What does term CBD 420 mean or 420? the group eventually shortened their phrase to simply “4:20”, which ultimately evolved into a code-word that the teens used to mean consuming cannabis.

Check out the Urban Dictionary definition here on CBD 420 or the use of 420

In 1971, five high school students – Steve Capper, Dave Reddix, Jeffrey Noel, Larry Schwartz, and Mark Gravich – in San Rafael, California, calling themselves the Waldos because “their chosen hang-out spot was a wall outside the school”, used the term in connection with a 1971 plan to search for an abandoned cannabis crop that they had learned about, based on a treasure map made by the grower. The Waldos designated the Louis Pasteur statue on the grounds of San Rafael High School as their meeting place, and 4:20 p.m. as their meeting time. The Waldos referred to this plan with the phrase “4:20 Louis”. After several failed attempts to find the crop, the group eventually shortened their phrase to simply “4:20”, which ultimately evolved into a code-word that the teens used to mean consuming cannabis.

Mike Edison says that Steven Hager of High Times was responsible for taking the story about the Waldos to “mind-boggling, cult-like extremes” and “suppressing” all other stories about the origin of the term. Hager wrote “Stoner Smart or Stoner Stupid?”, in which he attributed the early spread of the phrase to Grateful Dead followers – after Reddix became a roadie for the Dead’s bassist, Phil Lesh – and called for 4:20 p.m. to be the socially accepted hour of the day to consume cannabis.Mike: See you at 420!

420 Day – Monday, April 20, 2020

Good Clean Love

GOOD CLEAN LOVE ORGANIC LUBRICANT

Good Clean Love Lubricants No Parabens or Petrochemicals (non-CBD)

Since 2003, Good Clean Love has been devoted to the health and well-being of our customers. This is why we always use the safest natural ingredients, and we use organic ingredients whenever possible. Our product formulations are based on the latest scientific research of sexual health and feminine hygiene – which is why our patented, Bio Match products are pH-balancing, and our organic personal lubricants are 100% iso-osmatic. This means our products will not damage vaginal tissue, which is in contrast to many conventional personal care products on the market today.

Almost Naked Organic Personal Lubricant

If you are looking to relieve daily vaginal discomfort, enhance your lovemaking, or improve your daily hygiene routine, Good Clean Love has you covered. Our doctor-recommended products use organic ingredients, are pH-balancing, and are free of petrochemicals, parabens, hormones and artificial fragrance. 

Our certified organic, water-based lubricant is pH-balanced while helping you enhance your love life naturally. Made with aloe vera and infused with lemon and vanilla for a light flavor, our organic formula provides long-lasting glide without irritating chemicals or sticky cleanup.

In 2018, Almost Naked became the first carbon neutral personal lubricant. For every bottle of Almost Naked purchased, we will donate to a project that reduces greenhouse gases by an amount equivalent to that bottle’s carbon footprint

Vaginal Care

Recommended by gynecologists nationwide, our patented Bio Match™ Vaginal Care products help women of all ages relieve dryness and discomfort, maintain healthy pH balance and naturally eliminate odors. These products are made with organic ingredients and are free from parabens, petrochemicals and artificial fragrances.

Our Story

Intimacy products are designed to enhance pleasure, not to create side effects such as itching and burning. This is why we created Good Clean Love and why we’re so particular about our ingredients.

We use organic wherever possible, and always use natural ingredients. You can rest assured that Good Clean Love organic products never contain petrochemicals. We even put love and care into our packaging. Good Clean Love is the only organic feminine care and intimacy product company using green plastics made of recyclable sugar cane.

Shop all Good Clean items here

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